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    Jul 01, 2010· Sildenafil is a selective inhibitor of cyclic guanosine monophosphate‐specific phosphodiesterase‐5 that has been shown to improve exercise capacity, quality of life (QOL), and hemodynamics in human patients with symptomatic PAH. 6-10 It enhances nitric oxide mediated pulmonary vasodilatation and is believed to have additional beneficial .

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